Ocular surface

Pterygium — restoring a healthy ocular surface

A pterygium is a fibrovascular conjunctival growth that gradually spreads onto the cornea, linked to chronic ultraviolet exposure. It particularly affects people exposed to sun, wind and dust — sailors, farmers, outdoor athletes — and can remain symptom-free for a long time before becoming bothersome. Do you have persistent redness or a foreign body sensation, or have you noticed a recent change in your prescription? A pterygium can induce astigmatism and, if it progresses toward the visual axis, affect your vision.

Prevention relies on rigorous sun protection, which is effective in slowing or stabilizing the lesion. When surgery is indicated, I perform a conjunctival autograft with fibrin glue (Tisseel®), the current reference technique, which offers a low recurrence rate — around 5% at 10 years in published series (Daponte 2019).

UV-related condition Ocular surface Conjunctival autograft Fibrin glue Low recurrence
Slit-lamp photograph: nasal pterygium growing onto the cornea — fibrovascular tissue with new blood vessels, inner corner of the eye
Understanding

What is a pterygium? — an invasive fibrovascular tissue

A pterygium is a benign but progressive growth of conjunctival tissue rich in fibroblasts and blood vessels. It usually starts at the inner canthus (the inner corner of the eye, on the nose side) and slowly progresses toward the visual axis. Understanding its origin and mechanisms helps you prevent it and decide on the timing of surgery.

Structure

Fibrovascular tissue

A growth of conjunctiva with active fibroblasts and new blood vessels. Slow, progressive growth starting from the corneoscleral limbus. Pigmentation is often present in people with darker skin.

Mechanism

Fibroblast activation

Chronic UV exposure → DNA damage in the conjunctiva → activation of limbal fibroblasts → production of collagen and angiogenic factors → progressive tissue growth.

Clinical signs

Progressive symptoms

Redness (vasodilation), gritty sensation, induced astigmatism (if it reaches the axis), reduced vision when advanced.

Course

Progression toward the axis

The rate varies with individual factors and exposure. It may remain stable for years or progress quickly. Encroachment on the visual axis = risk of astigmatism + reduced visual acuity → indication for surgery.

Predisposition

Risk factors — who is affected

Pterygium mainly affects people exposed to the elements. Some factors increase the risk dramatically.

Factors that increase the risk

  • Chronic sun exposure without protection (UV, infrared)
  • Arid climate, wind, dust (desert, windy coastlines)
  • Intensive outdoor activities — sailors, farmers, athletes (skiing, windsurfing, mountain sports)
  • Tropical regions — latitudes close to the equator
  • Men aged 30–60 (more common in men)
  • Chronic dry eye (aggravating factor)
  • Prolonged past exposure (even long ago) counts

Warning signs: when to suspect it?

  • Whitish-pinkish growth near the nose on the surface of the eye
  • Persistent localized redness on the nasal side
  • Recent change in prescription — new or increased astigmatism
  • Glare discomfort or localized photophobia
  • Gritty sensation or chronic irritation
  • History of outdoor work or living in an arid climate
  • Pterygium in the other eye — risk of both eyes being affected
Public health

Pterygium worldwide — a public health issue

Pterygium is one of the common disorders of the ocular surface, especially in tropical and sunny regions. Its prevalence varies widely depending on latitude, UV exposure and the population studied.

5–25%
Prevalence in tropical regions (Liu 2013, Rezvan 2018)
Rare
In mainland France — low prevalence, underestimated because often asymptomatic
× 2–5
Increased risk with chronic UV exposure (Threlfall 1999)
40–60 yrs
Peak incidence (Liu 2013)

Why treat a pterygium?

  • Increasing discomfort — redness, irritation, gritty sensation
  • Induced astigmatism — if it reaches the optical zone, it changes the refraction
  • Cosmetic concern — appearance considered unsightly
  • Corneal complications — epithelial damage, loss of clarity (rare but possible)
  • Quality of life — discomfort during outdoor work, associated allergy

When to consider surgery?

  • Documented visual impairment — reduced acuity, bothersome astigmatism
  • Rapid progression toward the visual axis — getting close to the axis
  • Chronic inflammation — persistent redness despite treatment
  • Functional discomfort — unable to wear contact lenses, major discomfort
  • Cosmetic reasons — if the patient is motivated and the pterygium is visible
  • Young patient — all the more pressing given the long future exposure
Essential

Preventing pterygium — sun protection is essential

The best weapon against pterygium is prevention. If you have risk factors or an early pterygium, rigorous sun protection can slow or stop its progression.

Preventive measures

  • UV400 sunglasses in a wraparound style — they cover the sides near the nose, where pterygium develops
  • Cap or wide-brimmed hat — also protects against wind and dust
  • Regular artificial tears during prolonged exposure to wind, dust or dry air
  • Adequate hydration — prevents associated dry eye
  • Avoid midday exposure at altitude, at sea or on snow (UV reflection)
  • Yearly check-up if you have an early pterygium → monitoring of progression

Practical tips for outdoor work

  • Sailors, farmers, athletes: invest in polarized UV400 lenses
  • Beach/mountains: reapply tears every 2–3 hours
  • Dry/hot areas: a cap is essential; humidify the surrounding air (spray)
  • Children: UV sunglasses from a very young age (early sun protection matters most)
  • After surgery: LIFELONG sun protection (just as crucial to prevent recurrence)
How it is confirmed

Diagnosing pterygium — the clinical approach

The diagnosis is usually straightforward on clinical examination, but several tests complete the assessment to evaluate the functional impact and plan treatment.

Key examination

Slit lamp

Direct view of the pterygium: size, vascularity, pigmentation, corneal encroachment (measured in mm from the limbus). Checks for associated inflammation.

Monitoring

Surface photography

Documentation at every visit: comparison of size and appearance over time. Crucial if monitoring is chosen rather than immediate surgery.

Quantification

Corneal topography

If astigmatism is suspected (pterygium can induce it). Precise measurement of corneal curvature → quantifies the induced astigmatism and its axis.

Differential diagnosis

Anterior segment OCT

High-resolution optical imaging of the surface — helps with the differential diagnosis (pterygium vs pinguecula vs dermoid) and assesses tissue thickness.

Medical options

Conservative medical treatment — when not to operate right away

If the pterygium does not affect vision and remains stable, monitoring and symptomatic treatment are sufficient. Several measures reduce inflammation and slow progression.

Treating the symptoms

  • Preservative-free artificial tears — apply 4–6 times a day in case of irritation. Preservatives (BAK) worsen dryness and inflammation
  • Short courses of topical anti-inflammatories — NSAIDs (ketorolac eye drops) or mild corticosteroids (fluorometholone) during inflammatory flare-ups (1–2 weeks maximum). Never continuously
  • Night-time eye cover — if the eye is red in the morning (night-time dryness makes it worse)
  • Topical sunscreen — protect the nose area during intense exposure

Monitoring and timing of surgery

  • Visit every 3–6 months once a pterygium is detected (photography + measurement)
  • If stable → continued monitoring, no surgery
  • If rapidly progressing toward the axis → surgical opinion within 3–6 months
  • If the induced astigmatism is bothersome → discuss surgery, even if the axis is not involved
  • The patient's role — sun protection, regular tears, self-monitoring of progression
Reference technique

Pterygium surgery — conjunctival autograft + fibrin glue

When surgery is indicated, conjunctival autograft with fibrin glue is the current reference technique. It has the best known risk-benefit profile: short recovery and a low long-term recurrence rate.

20–30 min
Surgery time (outpatient)
~5%
Recurrence at 10 years (Daponte 2019)
High
Satisfaction (relief of discomfort and refractive stability)
Tisseel®
Fibrin glue + biological sealing

Steps of the procedure

  1. Local anesthesia — topical eye drops (lidocaine/oxybuprocaine). ± light sedation if anxious
  2. Complete excision of the pterygium — head, body and base down to Tenon's capsule. All diseased tissue is removed to reduce recurrence
  3. Harvesting the conjunctival graft — usually from the upper part of the eye (3 mm above the limbus). Autograft = a graft taken from the patient's own eye (no rejection)
  4. Positioning the graft — sutured or glued over the excised area. Its role: a mechanical barrier + a source of healthy epithelium
  5. Applying fibrin glue — Tisseel® (fibrinogen + thrombin) provides hemostasis and sealing. Advantages over sutures: less inflammation, less pain, better healing

Fibrin glue vs sutures

Advantages of glue: less inflammatory reaction, reduced post-operative pain, shorter operating time, favorable healing. Significantly lower recurrence with glue (Maiti 2017 meta-analysis, Cornea).

No routine mitomycin C in my practice: it is reserved for recurrences or high-risk cases. Autograft + fibrin glue makes it possible to avoid mitomycin C in the vast majority of primary pterygia.

At Cabinet OPHTALIFE — my surgical practice

How I treat your pterygium

1 · Pre-operative assessment

Complete evaluation under the microscope

Detailed slit-lamp examination: size of the pterygium, corneal extension (mm), vascularity, pigmentation, induced astigmatism (topography). Photographs. Tear film assessment. All the criteria that determine the timing of surgery.

2 · Surgical technique

Autograft + fibrin glue in a single procedure

I always perform a conjunctival autograft with fibrin glue (Tisseel®). Local anesthesia, low rate of vascular complications. The graft is taken from the upper conjunctiva, positioned precisely and secured with glue. No sutures. Duration: ~20–25 min. Outpatient.

3 · Recovery and prevention

LIFELONG sun protection is essential

Immediately after: intensive tears, protective shield for 24–48h. In the long term: wraparound UV400 sunglasses, a cap, avoiding midday sun at altitude or by the sea. With rigorous sun protection, the risk of recurrence remains around 5% at 10 years (Daponte 2019).

A detailed discussion with each patient: timing of surgery depending on discomfort, speed of progression and occupation (outdoor work weighs in the decision). Informed consent covering the technique, expected results and prevention of recurrence. Your daily commitment to sun protection directly determines the long-term risk of recurrence.

Surgical consultation ↗
After the procedure

Recovery — the healing process

The first weeks are critical for the graft to take. Here is the expected course and what you will feel.

D0 (day of surgery)

Immediately after

The eye may be swollen, with mild pain. Protective shield in place. Intensive tears (every 30 min). Complete rest. Residual anesthesia for 2–4h.

D1–D3

Moderate pain for 24–48h

Sensitivity to light (photophobia). Slightly red eye. The shield is usually removed on day 1 after a check-up. Tears every 1–2h. Simple painkillers (paracetamol/acetaminophen, NSAIDs if tolerated) if there is pain.

D+7

1-week check-up

Graft integrated, glue absorbed. Slit-lamp examination: appearance of the graft, epithelial healing. Removal of sutures if used (rare, usually glue only). Return to light work.

M+1

1 month: well healed

Residual redness, excellent graft appearance. Gradual return to activities (sports, screens). Rigorous sun protection now REALLY begins. Follow-up visit.

M+3 to M+6

Final healing

Graft stabilized. Redness almost back to normal. Stable vision (the astigmatism induced by the pterygium is generally reduced or even gone). Monitoring visit. Refraction if the astigmatism has changed.

Yearly

Long-term follow-up

Yearly monitoring after a history of pterygium. Follow-up photographs to detect early recurrence (localized redness in the same place, an early growth). Sun protection maintained for life.

Safety profile

Risks and complications — what you need to know

Like any surgical procedure, pterygium surgery carries risks. They are rare overall with the modern technique, but you should be aware of them.

Expected outcomes

  • Low recurrence — ~5% at 10 years (Daponte 2019)
  • Relief of discomfort — redness and irritation resolve within 1–3 months
  • Improved acuity — if induced astigmatism was present beforehand
  • Long-lasting result — the graft remains stable permanently

Intraoperative risks

  • Subconjunctival hematoma / bruising — resolves within 2–3 weeks
  • Corneal perforation — rare with careful dissection, but serious if it occurs
  • Infection — prevented by topical antibiotics after surgery
  • Poor glue adhesion — may require one or two additional micro-sutures

Post-operative complications

  • Recurrence — ≈ 5% at 10 years after autograft + fibrin glue (Daponte 2019). Varies with technique, sun protection and individual factors
  • Visible conjunctival scar — residual redness of the graft for 1 to 3 months, then fading
  • Conjunctival granuloma — rare, removed surgically if bothersome
  • Graft necrosis — very rare, may require a new graft
  • Temporary astigmatism — improves within 2–3 months
  • Prolonged photophobia — may last 4–6 weeks
  • Dellen / symblepharon — very rare (localized corneal thinning or adhesion between eyelid and conjunctiva)
  • Resuming contact lenses — postponed for at least 1 month
Long term

Preventing recurrence — lifelong sun protection

Recurrence is the main risk. Here are the strategies to minimize it.

Causes of recurrence

  • Continued prolonged UV exposure — the main factor
  • Incomplete excision of the primary pterygium — active residual fibrovascular tissue
  • Genetic / inflammatory predisposition — some patients are more prone
  • Untreated dry eye — an aggravating factor to correct beforehand

Prevention strategies

  • RIGOROUS lifelong sun protection — wraparound UV400 sunglasses every day outdoors
  • Cap/hat at all times in sunny areas or during outdoor work
  • Regular artificial tears in case of dryness or wind exposure
  • Yearly monitoring — follow-up photos, early detection of recurrence
  • Avoid midday exposure at altitude, at sea and in reflective environments

If a recurrence occurs

  • Repeat surgery is possible — re-excision + conjunctival autograft, usually reinforced
  • Intraoperative mitomycin C — an antifibroblastic agent applied briefly, reserved for recurrences to limit renewed growth
  • Amniotic membrane — a useful alternative or addition in complex cases (multiple recurrences, fragile ocular surface, severe dry eye)
  • Recurrence after repeat surgery — with autograft + MMC or amniotic membrane, the recurrence rate falls to ≈ 5–20% in modern series (Hirst, Surv Ophthalmol 2003; recent reviews). The high figures of the past (50% and more) concerned bare excisions without a graft
  • Bottom line: the quality of the first surgery is decisive, and sun protection remains the best prevention

Do you recognize these symptoms? Start with a consultation

I offer a complete assessment under the microscope to evaluate your pterygium and discuss the best plan together: close monitoring or surgery, depending on your situation.

Book an appointment ↗
Your journey

4 steps in your care — from diagnosis to prevention

1

Initial consultation

Slit lamp, photographs, astigmatism assessment, tear film. Diagnosis confirmed.

2

Treatment decision

Monitoring vs surgery depending on discomfort, progression and occupation. Detailed consent if surgery is chosen.

3

Surgery + recovery

Outpatient autograft + fibrin glue. Intensive tears, protective shield, regular check-ups on day 1, at 1 month and at 3 months.

4

Lifelong prevention

Rigorous sun protection, yearly photographic follow-up. Monitoring for recurrence and overall eye health.

Frequently asked questions

FAQ — your questions answered

Next step

Bothered by it every day? Let's take stock

I offer a complete assessment of your ocular surface and a detailed discussion of the options: monitoring and sun protection if the pterygium is stable, or surgery with conjunctival autograft + fibrin glue if its progression or your discomfort justify it.

Cabinet OPHTALIFE — Boulogne-Billancourt (near Paris)
Former assistant surgeon, Hôpital des Quinze-Vingts (Paris)
Book online via Doctolib
Related conditions

Related pages — learn more

Ocular surface
Dry eye disease
A common background that worsens pterygium symptoms. Diagnosis and treatment (artificial tears, IPL).
Read →
Ocular surface
IPL — Treating ocular surface disease
Intense pulsed light for associated chronic conjunctival inflammation.
Read →
Corneal surgery
Corneal transplant
If the pterygium progresses to severe corneal damage (rare).
Read →
Bibliography

Scientific references

This page is based on clinical data and reference publications in ocular surface ophthalmology. All sources can be verified.

  1. 1

    Daponte PL, Cigna A, Barboni P, et al. Conjunctival Autograft With Fibrin Glue for Pterygium: A Long Term Recurrence Assessment. Med Hypothesis Discov Innov Ophthalmol. 2019;8(4):272-277.

  2. 2

    Maiti R, Mukherjee S, Hota D. Recurrence Rate and Graft Stability With Fibrin Glue Compared With Suture for Conjunctival Autograft Adherence in Pterygium Surgery: A Meta-Analysis. Cornea. 2017;36(10):1285-1294.

  3. 3

    Hirst LW. The treatment of pterygium. Surv Ophthalmol. 2003;48(2):145-180.

  4. 4

    Coroneo MT. Pterygium as an early indicator of ultraviolet insolation. Br J Ophthalmol. 1993;77(11):734-739.

  5. 5

    McMonnies CW. Eye rubbing and pterygium. Cont Lens Anterior Eye. 2017;40(1):1-7.

  6. 6

    Liu L, Wu J, Geng J, Yuan Z, Huang D. Geographical prevalence and risk factors for pterygium: a systematic review and meta-analysis. BMJ Open. 2013;3(11):e003787.

  7. 7

    American Academy of Ophthalmology. Preferred Practice Pattern (PPP) — Conjunctivitis and Ocular Surface Disorders. aao.org

  8. 8

    Rezvan F, Khabazkhoob M, Hooshmand E, Yekta A, Saatchi M, Hashemi H. Prevalence and risk factors of pterygium: a systematic review and meta-analysis. Surv Ophthalmol. 2018;63(5):719-735.

  9. 9

    Threlfall TJ, English DR. Sun exposure and pterygium of the eye: a dose-response curve. Am J Ophthalmol. 1999;128(3):280-287.

The content of this website is for information purposes only and does not replace a medical consultation. Any treatment decision should be made together with your ophthalmologist.